Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of Ganoderma Lucidum
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چکیده
منابع مشابه
New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against f...
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Ganoderma lucidum is a well-known traditional Chinese medicinal herb containing many bioactive compounds. Ganoderic acid T (GA-T), which is a lanostane triterpenoid purified from methanol extract of G. lucidum mycelia, was found to exert cytotoxicity on various human carcinoma cell lines in a dose-dependent manner, while it was less toxic to normal human cell lines. Animal experiments in vivo a...
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Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, regulation of GA biosynthesis by various signaling remains poorly understood. This study investigated the role of apoptosis signaling on G...
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The effects of oxygen supply on the submerged fermentation of Ganoderma lucidum, a famous traditional Chinese medicinal mushroom, for simultaneous production of bioactive compounds—Ganoderma polysaccharide and ganoderic acid (GA) were studied. An initial volumetric oxygen transfer coefficient (KLa) value within the range of 16.4–96.0 h−1 had a significant effect on the cell growth, cellular mor...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2006
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x0600100501